Excessive sugar consumption damages intestinal walls and causes colitis

The protective mucus that lines the epithelium of the large intestine has thinned in mice that have been given too much sugar. In a new study, this led to inflammatory bowel disease (IBD) or colitis in the test animals. In addition, researchers who examined their colon found more bacteria that can damage this protective layer of mucus in the intestine.

How excessive sugar consumption promotes inflammatory bowel disease

increased risk of inflammatory bowel disease due to too much sugar in the diet

Colitis is a major public health problem in most Western countries, according to the study authors. IBD can even cause persistent diarrhea, abdominal pain, and rectal bleeding. The number of adults suffering from such a disease has increased enormously in recent years, according to information. In addition, colitis is also evident in children who have not historically suffered from it. Due to the much higher prevalence of the disease in Western countries, researchers have viewed the Western diet, which is high in fat, sugar, and animal protein, as a possible risk factor. While high-fat diets were found to induce IBD, the role of sugar was more controversial, according to the study authors.

Healthy and unhealthy intestinal bacteria in the microbiome Excessive sugar consumption increases the risk of colitis

In the study, excessive sugar consumption from the glucose in high-fructose corn syrup emerged as the prime suspect. This ingredient was developed by the food industry in the 1960s and then increasingly used to sweeten soft drinks and other foods. The incidence of this type of colitis has also increased in Western countries over the same period. This is especially true in children, according to the study. The researchers found that mice that were either genetically predisposed to developing colitis or given a chemical that causes IBD developed more severe symptoms when given sugar first.

Study results

intestinal microbiome consists of harmful and healthy bacteria

Researchers used gene sequencing techniques to identify specific types and prevalence of bacteria. Those found in the colon of mice before and after receiving their sugar regimen. After seven days, excessive sugar consumption in mice fed sucrose, fructose and glucose showed significant changes in the gut microbiome. Bacteria known to produce degrading enzymes such as Akkermansia have been found in greater numbers. Some other types of gut bacteria that are considered healthy and commonly found in the gut microbiome, such as Lactobacillus, are less common. So the researchers saw evidence of a thinning of the mucous layer that protects the lining of the colon.

healthy nutrition with natural products supports the metabolism and the intestine through lactobacillus bacteria

They also saw signs of infection from other bacteria. The mucous layer protects the intestinal mucosal tissue from the penetration of intestinal microbiota. A higher frequency of degrading bacteria, including Akkermansia muciniphila and Bacteroides fragilis, in mice treated with glucose is therefore a potential risk for the intestinal mucous barrier. After the researchers found changes in the microbiome in sugar-fed mice, they fed samples from the former to other laboratory mice. These mice developed colitis worse. This suggests that the glucose-induced susceptibility to colitis, along with the destructive gut microbiota, can be transmitted from affected animals. Researchers are planning this study further investigate the effects of high sugar intake. This will help you determine how this affects the development of other inflammatory diseases such as obesity, fatty liver disease, and neurodegenerative diseases such as Alzheimer’s.